This has been a puzzle to historians who presume that Christianity was first spread in Egypt through St. Marc, one of the Apostles who preached the Gospel in Alexandria where he established his famous church. Later on this church became one of the greatest in the country. Christianity spread during the 2nd century with Clement and Originus and the Christian community larger in number started the foundation of the Christian School in Alexandria that was described to be the equivalent of a Christian university that grew to become an important center for theology study. The Roman emperor, Septime Severe ordered the closure of the church and the dean Clement was expelled, but despite these obstacles, the school was able to overcome all the difficulties and regained its stature later.

Christianity was strongly fought at its early stages and followers were fiercely persecuted, particularly during Dekledianos reign. The Roman emperor was known by his cruelty and the unmerciful way he treated Christians. Romans, in general spare no way of persecution they treated the believers with, and Christians later considered the year 284 AD as the Martyr era. Many had died and had been executed just for being Christians during that period considered the worst for Christianity. This led the Christians to run away in order to escape this discrimination and a tendency to celibate spread, they found refuge in deserts and mountain caves where they could freely practice their cult and rituals, their religion being banned in public. This situation lasted until the reign of Constantine, but as a result, priesthood was established and monasteries, considered as a shelter to the runaways, were built all over the country and expanded later to become an international tendency. The new religion, officially recognized by Constantine in 395 AD, continued to be ever since till the Arab conquest in 641AD.
This period has a great significance as its represents the link between the Greco- Roman Period and the Islamic Period.